Hexokinase 2 as oncotarget
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چکیده
منابع مشابه
Hexokinase 2 as oncotarget
It is well established that cancer cells differ from most somatic adult cells by their high rate of aerobic glycolysis despite oxidative phosphorylation. This distinct property of cancer cells is often used for tumor imaging in vivo following the administration of the labeled glucose analog, fluoro deoxy glucose (FDG). The high uptake of the labeled FDG in cancer cells can then be detected by p...
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In recent years the tumor microenvironment has emerged as an important target for cancer therapy. The tumor microenvironment facilitates tumor progression and metastasis by providing a matrix for the integration of intricate networks suitable to maintain and nourish tumor cells, as well as suppress the normal immunologic antitumor defenses. However, the details of the pathways in the tumor micr...
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The cap-dependent mRNA translation process that enables post-transcriptional control of gene expression and protein synthesis is tightly regulated in eukaryotes. Deregulation of this process, particularly in the formation of the eIF4F translation initiation complex— comprising the eIF4E mRNA cap-binding protein, the eIF4G scaffolding protein and the eIF4A RNA helicase—is associated with cancer ...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2013
ISSN: 1949-2553
DOI: 10.18632/oncotarget.1563